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Reliability guarantee framework for the Sichuan–Tibet Railway

Frontiers of Engineering Management 2021, Volume 8, Issue 4,   Pages 480-491 doi: 10.1007/s42524-021-0170-4

Abstract: This study proposes a novel reliability framework to guarantee the ideal operation state of the Sichuan–Tibet

Keywords： Sichuan–Tibet Railway     operational efficiency     reliability guarantee     Nine-Connotation     implementation    

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Research on China’s Development Strategy for Marine Transportation Engineering

Task Force for the Study on Development Strategy of China’s Marine Engineering and Technology Marine Transportation Research Group

Strategic Study of CAE 2016, Volume 18, Issue 2,   Pages 10-18 doi: 10.15302/J-SSCAE-2016.02.002

Abstract:

Marine transportation technology is the indispensable element requried for the marine exploration, ocean development, ocean resources management and maintaining China's maritime rights and interests. This paper identifies China's strategic needs for the the development of the marine transportation engineering capabilities and technology. At the same time, it also provides a in-depth analysis of the domestic and international development situation to map out the developmental direction and trends of future marine transportation engineering and technology in terms of the strategic positions, goals, strategic tasks and key areas of development for marine transportation equipment in China. Finally, this paper puts forward some policy measures and advice for the relevant departments of the industry to consider.

Keywords： marine transportation equipment     important guarantee     engineering and technology     development strategy    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive cell therapy    

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Elements’ important ranking of China drug safety management system: applying the non-structural

Xiaoping ZHENG, Xiaocui WANG, Tingkuan ZHONG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 290-299 doi: 10.1007/s11705-009-0283-5

Abstract: Drug safety management is an important issue in China drug management system and attracts great attentionsIn order to reduce drug incident, this study discusses some important elements associated with ChinaBesides, a methodology for rating the important elements is described and applied.The results indicate that the sample systems are the most important in these important elements, andThis study not only points out the important ranking of the pivotal elements in China drug safety management

Keywords： management system     different     management     important ranking     non-structural fuzzy    

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Service Security of Underwater Tunnel Lining Structures and Corresponding Guarantee Countermeasures

He Chuan,Liu Sijin,Zhang Yuchun and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6,   Pages 44-51 doi: 10.15302/J-SSCAE-2017.06.007

Abstract:

This paper analyzes four aspects of the safety problems in tunnel lining structures: design and construction, environmental erosion, sudden natural disasters, and sudden accidents. A survey of underwater tunneling such as the Huangpu River’s cross-river tunnel and the underground traffic tunnel in Shanghai was carried out, and the status quo of China’s underwater tunnel lining structure was analyzed. Based on these analyses, countermeasures guaranteeing the long-life security of underwater tunnel structures are being sought regarding tunnel construction, structural performance degradation, sudden natural disasters, and sudden accidents. These countermeasures are being sought to effectively protect and ensure the service performance of the tunnel structures during their entire life cycle. These security measures can ensure the safe performance of the structure during its entire life cycle, even under long service times. This research can serve as a reference for enhancing the structural security of underwater tunnels and other major tunnel structures.

Keywords： underwater tunnels     service security     security guarantee countermeasures     long life     structural defects    

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Presentation of machine learning methods to determine the most important factors affecting road traffic

Hamid MIRZAHOSSEIN; Milad SASHURPOUR; Seyed Mohsen HOSSEINIAN; Vahid Najafi Moghaddam GILANI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 5,   Pages 657-666 doi: 10.1007/s11709-022-0827-z

Abstract: The purpose of this research was to develop statistical and intelligent models for predicting the severity of road traffic accidents (RTAs) on rural roads. Multiple Logistic Regression (MLR) was used to predict the likelihood of RTAs. For more accurate prediction, Multi-Layer Perceptron (MLP) and Radius Basis Function (RBF) neural networks were applied. Results indicated that in MLR, the model obtained from the backward method with the correct percent of 84.7% and R2 value of 0.893 was the best method for predicting the likelihood of RTAs. Also, MLR showed that the variables of not paying attention to the front not paying attention to the frontroad ahead, followed byand then vehicle-motorcycle/bike accidents were the greatest problems. Among the models, MLP had a better performance, so that the prediction accuracy of MLR, MLP, and RBF were 84.7%, 96.7%, and 92.1%, respectively. MLP model, due to higher accuracy, showed that the variable of reason of accident had the highest effect on the prediction of accidents, and considering MLR results, the variables of not paying attention to the front and then vehicle-motorcycle/bike accidents had the most influence on the occurrence of accidents. Therefore, motorcyclists and cyclists are more prone to accidents, and appropriate solutions should be adopted to enhance their safety.

Keywords： safety     rural accidents     multiple logistic regression     artificial neural networks    

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Genomic regions under selection for important traits in domestic horse breeds

Xuexue LIU, Yuehui MA, Lin JIANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 289-294 doi: 10.15302/J-FASE-2017155

Abstract: studies and genome wide analyses to identify the genomic regions targeted by positive selection for four important

Keywords： horse     coat color     racing performance     gait     height    

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Safety Guarantee Measures for Subsea Shield Tunnel Segments Based on Life Cycle Deterioration Analysis

Liu Sijin,He Chuan,Sun Qi and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6,   Pages 52-60 doi: 10.15302/J-SSCAE-2017.06.008

Abstract:

The segment joint is the weak link in the lining structure of subsea tunnels, as it is under the continuous coupled effect of high water pressure and the corrosive seawater environment. If its performance deteriorates, it will seriously affect the safety of the lining structure of entire subsea shield tunnels. Based on an analysis of existing research into segment joint erosion and deterioration, a tunnel service time factor is introduced. Considering the influence of seawater pressure infiltration and chloride ion erosion and migration, a model analyzing the erosion and deterioration of the segment joint over its whole life cycle was subsequently established. The law governing the progressive erosion and deterioration of the segment joints of subsea tunnels over the entire life cycle was analyzed. The effects of seawater pressure and ion concentration on the erosion, deterioration, and steel corrosion of segment joints were studied. Based on the analysis of erosion and deterioration over the entire life cycle, economic and rational measures to ensure the long-term safety of the segment lining structure of subsea shield tunnels were proposed.

Keywords： shield tunnel     safety guarantee     deterioration analysis     ion erosion     segment joint    

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Genetic Crop Improvement: A Guarantee for Sustainable Agricultural Production

Jianmin Wan

Engineering 2018, Volume 4, Issue 4,   Pages 431-432 doi: 10.1016/j.eng.2018.07.019

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Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 279-288 doi: 10.15302/J-FASE-2017151

Abstract: Sheep are one of the most economically important domesticated animals for human society.Additionally, comprehensive information on functional genes and genetic variants associated with economically important

Keywords： sheep     high-throughput screening     productive traits     genome-wide studies    

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Five important issues in the present field of knowledge discovery

Yang Bingru

Strategic Study of CAE 2009, Volume 11, Issue 4,   Pages 76-83

Abstract:

In this paper, the author summarized and proposed five important issuesin the present field of knowledge discovery and data mining, which comprise two important core issues, two conjectures, challenge issues in mainstream development, important issues of relevant fields in

Keywords： important core issues in KD     conjectures in KD     challenge issues in KD     protein secondary structure prediction    

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“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

Frontiers of Engineering Management 2020, Volume 7, Issue 2,   Pages 304-307 doi: 10.1007/s42524-019-0079-3

Abstract: Xiaobo WANG. [J]. Front. Eng, 2019, 6(1): 131-137.Peter REDFERN, Hua ZHONG. [J]. Front. Eng, 2017, 4(2): 193-200.Qixiang FAN. [J]. Front. Eng, 2017, 4(2): 231-237.Ming-zhou Liu,Cong-hu Liu,Mao-gen Ge,Yuan Zhang,Qing-hua Zhu. [J]. Front. Eng, 2016, 3(2): 144-146.Yu Zhao,Sheng-quan Wang,Ke-chao Zhu. [J]. Front. Eng, 2015, 2(1): 35-38.Ru-gui Chen,Jia-meng Chen. [J]. Front. Eng, 2014, 1(1): 52-61.An Wang. [J]. Front. Eng, 2014, 1(1): 13-17.

Keywords： permafrost protection     sustainable development     health guarantee system    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia (SCAP). We prospectively enrolled consecutive SCAP patients admitted to ICU. Bronchoscopy was performed at bedside within 48 h of ICU admission, and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid. The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy. Sixty-seven patients were included. Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota (R2=0.033; P=0.018), followed by acute kidney injury (AKI; R2=0.032; P=0.011) and plasma MIP-1β level (R2=0.027; P=0.044). Random forest identified that the families Prevotellaceae, Moraxellaceae, and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results. Multivariable Cox regression showed that the increase in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements. The positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung microbiota composition on ICU admission. The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale     Prevotellaceae    

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Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a

Ting Lin, Kai Qu, Xinsen Xu, Min Tian, Jie Gao, Chun Zhang, Ying Di, Yuelang Zhang, Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 118-126 doi: 10.1007/s11684-014-0306-6

Abstract:

Intensive care unit (ICU) is important in the rehabilitation of critically ill patients.

Keywords： intensive care unit     sclerosing cholangitis     ischemic injury     prognosis     systemic review    

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Contact of surfaces and contact characteristics of offset surfaces

CAO Lixin, GONG Hu, LIU Jian

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 318-324 doi: 10.1007/s11465-008-0067-5

Abstract: research such as optimization of cutter location and calculation of the geometrical cusp height are importantThe research results indicate that the relative normal curvature is an important geometrical invariant

Keywords： relative     important geometrical     relationship     geometrical invariant     calculation    

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Title Author Date Type Operation

Reliability guarantee framework for the Sichuan–Tibet Railway

Journal Article

Research on China’s Development Strategy for Marine Transportation Engineering

Task Force for the Study on Development Strategy of China’s Marine Engineering and Technology Marine Transportation Research Group

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Journal Article

Elements’ important ranking of China drug safety management system: applying the non-structural

Xiaoping ZHENG, Xiaocui WANG, Tingkuan ZHONG,

Journal Article

Service Security of Underwater Tunnel Lining Structures and Corresponding Guarantee Countermeasures

He Chuan,Liu Sijin,Zhang Yuchun and Feng Kun

Journal Article

Presentation of machine learning methods to determine the most important factors affecting road traffic

Hamid MIRZAHOSSEIN; Milad SASHURPOUR; Seyed Mohsen HOSSEINIAN; Vahid Najafi Moghaddam GILANI

Journal Article

Genomic regions under selection for important traits in domestic horse breeds

Xuexue LIU, Yuehui MA, Lin JIANG

Journal Article

Safety Guarantee Measures for Subsea Shield Tunnel Segments Based on Life Cycle Deterioration Analysis

Liu Sijin,He Chuan,Sun Qi and Feng Kun

Journal Article

Genetic Crop Improvement: A Guarantee for Sustainable Agricultural Production

Jianmin Wan

Journal Article

Recent advances in understanding genetic variants associated with economically important traits in sheep

Song-Song XU, Meng-Hua LI

Journal Article

Five important issues in the present field of knowledge discovery

Yang Bingru

Journal Article

“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Journal Article

Sclerosing cholangitis in critically ill patients: an important and easily ignored problem based on a

Ting Lin, Kai Qu, Xinsen Xu, Min Tian, Jie Gao, Chun Zhang, Ying Di, Yuelang Zhang, Chang Liu

Journal Article

Contact of surfaces and contact characteristics of offset surfaces

CAO Lixin, GONG Hu, LIU Jian

Journal Article